Gawande RS, Khurana A, Messing S, Zhang D, Castañeda RT, Goldsby RE, Hawkins RA, Daldrup-Link HE: Differentiation of normal thymus from anterior mediastinal lymphoma and lymphoma recurrence at pediatric PET/CT. Radiology. 262(2):613-22, 2012. PMID: 22157202

Khurana A, Nejadnik H, Gawande R, Lin G, Lee S, Messing S, Castaneda R, Derugin N, Pisani L, Lue TF, Daldrup-Link HE: Intravenous ferumoxytol allows noninvasive MR imaging monitoring of macrophage migration into stem cell transplants. Radiology. 264(3):803-11. 2012. PMID: 22820731

Daldrup-Link HE, Coussens LM: MR imaging of tumor-associated macrophages. Oncoimmunology. 1(4):507-509 2012. PMID: 22754769

Henning TD, Gawande R, Khurana A, Tavri S, Mandrussow L, Golovko D, Horvai A, Sennino B, McDonald D, Meier R, Wendland M, Derugin N, Link TM, Daldrup-Link HE: Magnetic resonance imaging of ferumoxide-labeled mesenchymal stem cells in cartilage defects: in vitro and in vivo investigations. Mol Imaging. 11(3):197-209. 2012. PMID: 22554484

Nejadnik H, Henning TD, Castaneda RT, Boddington S, Taubert S, Jha P, Tavri S, Golovko D, Ackerman L, Meier R, Daldrup-Link HE: Somatic differentiation and MR imaging of magnetically labeled human embryonic stem cells. Cell Transplant. 2012. PMID: 22862886

Rauschecker AM, Patel CV, Yeom KW, Eisenhut CA, Gawande RS, O'Brien JM, Ebrahimi KB, Daldrup-Link HE: High-resolution MR imaging of the orbit in patients with retinoblastoma. Radiographics. 32 (5): 1307-26. Sep-Oct 2012. PMID: 22977020

Matthay KK, Weiss B, Villablanca JG, Maris JM, Yanik GA, Dubois SG, Stubbs J, Groshen S, Tsao-Wei D, Hawkins R, Jackson H, Goodarzian F, Daldrup-Link HE, Panigrahy A, Towbin A, Shimada H, Barrett J, Lafrance N, Babich J: Dose escalation study of no-carrier-added 131I-metaiodobenzylguanidine for relapsed or refractory neuroblastoma: new approaches to neuroblastoma therapy consortium trial. J Nucl Med. 53(7):1155-63. 2012. PMID: 22700000

Nejadnik H, Daldrup-Link HE: Engineering stem cells for treatment of osteochondral defects. Skeletal Radiol. 41(1):1-4. 2012. PMID: 22072236

Henning TD, Gawande R, Khurana A, Tavri S, Mandrussow L, Golovko D, Horvai A, Sennino B, McDonald D, Meier R, Wendland M, Derugin N, Link TM, Daldrup-Link HE: MR Imaging of Ferumoxides labeled Mesenchymal Stem Cells in Cartilage Defects: in vitro and in vivo investigations. Molecular Imaging. 11(3). Jun 2012. PMID: 22554484.

Cover, September 2011 Clinical Cancer Research
Research of the Daldrup-Link lab was featured on the cover of the September 2011 issue of Clinical Cancer Research


Daldrup-Link HE, Golovko D, Ruffell B, Denardo DG, Castaneda R, Ansari C, Rao J, Tikhomirov GA, Wendland MF, Corot C, Coussens LM: MRI of tumor-associated macrophages with clinically applicable iron oxide nanoparticles. Clin Cancer Res. 17(17):5695-704. 2011. PMID: 21791632 PMCID: PMC3166957

Boddington S, Sutton EJ, Henning TD, Nedopil A, Sennino B, Kim A, Daldrup-Link HE: Labeling Human Mesenchymal Stem Cells with Fluorescent Contrast Agents: The Biological Impact. Mol Imaging Biol. 13(1):3-9, 2011. PMID: 20379785 PMCID: 3023037

Meier R, Golovko D, Tavri S, Henning TD, Knopp C, Piontek G, Rudelius M, Heinrich P, Reinhardt V, Heinrich P, Wels W, Daldrup-Link HE: Depicting adoptive immunotherapy for prostate cancer in an animal model with MR Imaging. Magn Res Med. 65(3):756–763, 2011; DOI: 10.1002/mrm.22652

Russell HV, Groshen SG, Ara T, DeClerck YA, Hawkins R, Jackson H, Daldrup-Link HE, Marachelian A, Skerjanec A, Park J, Katzenstein H, Matthay KK, Blaney SM, Villablanca JG: A phase I study of zoledronic acid and low dose cyclophosphamide in children with recurrent/refractory neuroblastoma: A New Approaches to Neuroblastoma Therapy (NANT) study. Pediatr Blood Cancer 57(2):275-82, 2011; PMID: 21671363. DOI: 10.1002/pbc.22821.

Nanoparticle-labeled beating cardiomyocytes, derived from
embryonic stem cells

Castaneda R, Boddington S, Wendland M, Henning TD, Mandrussow L, Daldrup-Link HE: MR Imaging of Human Embryonic Stem Cell Derived Cardiomyocytes: Should iron oxide nanoparticle labeling occur before or after differentiation? Pediatr Radiol. 41(11): 1384-1392, 2011. PMID: 21594541.

Daldrup-Link HE, Golovko D, DeNardo D, Russel B, Wendland M, Corot C, Coussens L: MR imaging of tumor associated macrophages with clinically applicable iron oxide nanoparticles. Clinical Cancer Research 17(17):5695-704, 2011. PMID: 21791632.


Sutton EJ, Henning TD, Boddington S, Demos S, Krug C, Meier R, Kornak J, Zhao S, Baehner R, Sharifi S, Daldrup-Link H. In Vivo Magnetic Resonance Imaging and Optical Imaging Comparison of Viable and Nonviable Mesenchymal Stem Cells with a Bifunctional Label. Mol Imaging. 9(5): 278-90, 2010. PMCID: 3060764

Golovko D, Henning T, Bauer JS, Settles M, Frenzel T, Mayerhofer A, Rummeny E, Daldrup-Link HE: Accelerated stem cell labeling with ferucarbotran and protamine. Eur Radiol. 20(3): 640-8, 2010. PMCID: 2822227

Boddington SE, Henning TD, Jha P, Schlieve C, Mandrussow L, DeNardo D, Bernstein HS, Ritner C, Golovko D, Zhao S, Daldrup-Link H. Labeling Human Embryonic Stem Cell Derived Cardiomyocytes with Indocyanine Green for Noninvasive tracking with Optical Imaging: An FDA Compatible Alternative to Firefly Luciferase. Cell Transplantation 19(1): 55-65, 2010. PMCID: 2939828

Meier R, Henning TD, Boddington S, Tavri S, Arora S, Corot C, Daldrup-Link HE: Breast cancers: MR imaging of folate receptor expression with the folate-specific nanoparticle P1133. Radiology 255(2):527-35, 2010. PMID: 20413763. DOI: 10.1148/radiol.10090050

Jha P, Froehlich A, McCarville B, Navarro O, Babyn P, Goldsby R, Daldrup-Link HE: Unusual association of alveolar rhabdomyosarcoma with pancreatic metastasis: Emerging role of PET-CT in tumor staging. Pediatric Radiology40:1380–1386, 2010. PMCID: 2895865

Meier R, Krug C, Golovko D, Boddington S, Piontek G, Rudelius M, Sutton E, Baur-Melnyk A, Fung-Jones E, Daldrup-Link HE: ICG-enhanced imaging of arthritis with an integrated optical imaging/x-ray system. Arthritis Rheum 62(8):2322-7, 2010. PMCID: 2921028

Nedopil A, Klenk C, Kim C, Golovko D, Li S, Wendland M, Daldrup-Link HE: MR Signal Characteristics of Viable and Apoptotic Human Mesenchymal Stem Cells in MASI for Treatment of Osteoarthritis. Invest Radiol. 45(10):634-40, 2010; PMCID: 2943569

Jha P, Bains S, Hostetter D, Golovko D, Li S, Krug R, Wendland M, Daldrup-Link HE: Monitoring NK cell immunotherapy using non-invasive imaging modalities. Cancer Research. 70(15):6109-13, 2010. PMCID: 2917347


Kleis E, Daldrup-Link HE, Matthay K, Goldsby R, Schreck C, Hawkins R, Franc B: Diagnostic value of PET/CT for the staging and restaging of pediatric tumors. Eur J Nucl Med Mol Imaging 36 (1): 23-36, 2009. PMID: 18719909. DOI: 10.1007/s00259-008-0911-1

Tavri S, Jha P, Meier R, Henning TD, Mueller T, Hostetter D, Knopp C, Johansson M, Reinhardt V, Boddington S, Sista A, Wels W, Daldrup-Link HE: Optical imaging of cellular immunotherapy against prostate cancer. Molecular Imaging 8(1): 15-26, 2009. PMID: 19344572

Wagner LM, Villablanca JM, Stewart CF, Crews KR, Groshen S, Reynolds P, Park JR, Maris JM, Hawkins RA, Daldrup-Link HE, Jackson HA, Matthay KK: Phase I Trial of Oral Irinotecan and Temozolomide for Children with Relapsed High-Risk Neuroblastoma: New Approaches to Neuroblastoma Therapy Consortium Study. J Clin Oncol. 27(8):1290-6, 2009. PMCID: 2667827

Henning TD, Wendland MF, Golovko D, Sutton EJ, Sennino B, Malek F, Bauer JS, McDonald DM, Daldrup-Link HE: Relaxation effects of ferucarbotran-labeled mesenchymal stem cells at 1.5T and 3T: discrimination of viable from lysed cells. Magn Reson Med 62(2):325-332, 2009. PMCID: 2931823

Henning TD, Sutton EJ, Kim A, Golovko D, Horvai A, Ackerman L, Sennino B, McDonald D, Lotz J, Daldrup-Link HE: The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cells and implications for MR imaging. Contrast Media Mol Imaging4(4): 165-173, 2009, PMCID: 2933782

Sutton E, Tong RT, Gillies A, Henning TD, Weinberg V, Boddington S, Haas-Kogan D, Matthay K, Gooding C, Whang ZJ, Yeh B, Coakley F, Daldrup-Link HE: Decreased aortic growth and middle aortic syndrome in patients with neuroblastoma after radiation therapy. Pediatric Radiology 39:1194–1202, 2009. PMCID: 2765626

Sista A, Knebel RJ, Tavri S, Johansson M, DeNardo D, Boddington SE, Kishore SE, Ansari C, Reinhart V, Coakley FV, Coussens LM, Daldrup-Link H. Optical imaging of the peri-tumoral inflammatory response in breast cancer 7(1):94, 2009. PMCID: 2780997

Sutton EJ, Boddington S, Nedopil A, Henning TD, Demos S, Baehner R, Sennino B, Lu Y, Daldrup-Link HE: An optical imaging method to monitor stem cell migration in a model of immune-mediated arthritis. Optics Express 17 (26): 24403–24413, 2009. PMCID: 2888495


Henning T, Weber A, Bauer JS, Meier R, Carlsen JM, Sutton EJ, Prevrhal S, Ziegler S, Feussner H, Daldrup-Link HE, Rummeny EJ: Imaging Characteristics of DHOG, a new hepatobiliary contrast agent for preclinical Micro-CT. Acad Radiol 15(3):342-9, 2008. DOI: 10.1016/j.acra.2007.10.007 PMID: 18280932

Wang J, Boddington S, Wendland M, Meier R, Corot C, Daldrup-Link HE: MR Imaging of Ovarian Tumors using Folate-Receptor targeted contrast agents. Pediatric Radiology 38(5):529-37, 2008. PMCID: 2745549. Of note, this manuscript received the “Berdon Award” from the Society for Pediatric Radiology for the best basic science paper, published in Pediatric Radiology in 2008

Meier R, Piert M, Piontek G, Rudelius M, Metz S, Uherek C, Wels W, Daldrup-Link HE: Tracking of FDG-18 labeled Natural Killer cells to HER2/neu positive Mammary Tumors. Nuclear Medicine and Biology 35(5): 579-88, 2008. DOI: 10.1016/j.nucmedbio.2008.02.006 PMID: 18589302

Boddington S, Sutton EJ, Jones EF, Purcell DD, Henning TD, Tavri S, Meier R, Sista A, Fu Y, Daldrup-Link HE: Improved Fluorescence of Indocyanine Green in vitro and in vivo after simple cooling procedures. Contrast Media & Molecular Imaging 3(5):191-197, 2008. DOI: 10.1002/cmmi.251 PMID: 18973215

Meier R, Boddington S, Krug S, Acosta S, Henning TD, Sutton EJ, Tavri S Lotz J, Daldrup-Link HE: Detection of postoperative granulation tissue with an ICG-enhanced integrated OI/X-ray system. J Transl Med. 6(1):73-76, 2008. PMCID: 2613387


Henning T, Saborowski O,Golovko D, Boddington S, Bauer J, Fy Y, Meier R, Pietsch H, Sennino B, Daldrup-Link HE: Cell labeling with the positive MR contrast agent Gadofluorine M. Eur Radiol 17(5):1226-34, 2007. DOI: 10.1007/s00330-006-0522-9 PMID: 17206428

Saborowski O,Simon G, Raatschen H, Wendland M, Fu Y, Knudsen M, Baehner R, Corot C, Chen MH, Daldrup-Link HE: MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agent. Contrast Media & Molecular Imaging 2(2):72-81, 2007. DOI: 10.1002/cmmi.128 PMID: 17385788

Gillies A, Sutton E, DeWitt KD, Matthay KK, Weinberg V, Fisch BM, Chan A, Gooding C, Daldrup-Link HE, Wara WM, Farmer DL, Harrison MR, Haas-Kogan D: Long-Term outcome and toxicities of intraoperative radiotherapy for high-risk neuroblastoma. Int. J. Radiation Oncology Biol. Phys 69(3):858-64, 2007. DOI: 10.1016/j.ijrobp.2007.04.006


Simon GH, von Vopelius-Feldt J, Fu Y, Schlegel J, Piontek G, Wendland MF,Mei-Hsiu C, Daldrup-Link HE: Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging of antigen-induced arthritis: a comparative study between SHU555C, Ferumoxtran-10 and Ferumoxytol. Investigative Radiology 41(1):45-51, 2006. PMID: 16355039

Simon GH, Daldrup-Link HE, von Vopelius-Feldt J, Wendland M, Fu Y, Schlegel J, Rummeny EJ: MRT der Arthritis mit dem neuen USPIO Resovist S: Optimierung des T1-Enhancements. (“MRI of arthritis with the USPIO SHU555C: Optimization of T1-Enhancement”) Fortschr. Röntgenstr. 178(2):200-6, 2006

Metz S, Lohr S, Settles S, Beer A, Woertler M, Rummeny EJ, Daldrup-Link HE: Ferumoxtran-10 enhanced MR imaging of the bone marrow before and after conditioning therapy in patients with Non Hodgkins Lymphoma. Eur Radiol. 16(3):598-607, 2006. DOI: 10.1007/s00330-005-0045-9 PMID: 16284770

Simon GH, Bauer J, Saborowski O, Fu Y, Corot C, Wendland MF, Daldrup-Link HE: T1 and T2 relaxivity of intracellular and extracellular USPIO at 1.5T and 3T clinical MR scanning. Eur Radiol. 16(3):738-45, 2006. DOI: 10.1007/s00330-005-0031-2 PMID: 16308692

Simon GH, von Vopelius-Feldt J, Wendland M,Fu Y, Piontek G, Schlegel J, Chen, MH, Daldrup-Link HE: MRI of arthritis: Comparison of ultrasmall superparamagnetic iron oxide vs. Gd-DTPA. Journal of Magnetic Resonance Imaging 23(5):720-7, 2006. DOI: 10.1002/jmri.20556 PMID: 16557494

Simon GH, Daldrup-Link HE, Kau J, Metz S, Schlegel J, Piontek G, Saborowski O, Demos S, Duyster J, Pichler BJ: Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe. Eur J Nucl Med & Mol Imaging, 33(9):998-1006; 2006. DOI: 10.1007/s00259-006-0081-y


Daldrup-Link HE, Rudelius M, Piontek G, Metz S, Bräuer R, Debus G, Corot C, Schlegel J, Link TM, Peschel C, Rummeny EJ, Oostendorp RAJ: Migration of iron oxide-labeled human hematopoietic progenitor cells in a mouse model: in vivo monitoring with 1.5-T MR imaging equipment. Radiology 234(1): 197-205, 2005. DOI: 10.1148/radiol.2341031236 PMID: 15618382

Daldrup-Link HE, Meier R, Rudelius M, Piontek G, Piert M, Metz S, Settles S, Uherek C, Schlegel J, Rummeny EJ: In-vivo Tracking of genetically engineered anti-HER2/neu directed Natural Killer to HER2/neu positive Mammary Tumors with Magnetic Resonance Imaging. Eur Radiol 15(1): 4-13, 2005. DOI: 10.1007/s00330-004-2526-7 PMID: 15616814

Simon GH, Link TM, Engelke C, Woertler K, Doebereiner F, Daldrup-Link HE, Settles M, Rummeny EJ: Detection of hepatocellular carcinoma: comparison of Gd-DTPA- and Ferumoxides-enhanced MR. Eur Radiol 15(5):895-903, 2005. DOI: 10.1007/s00330-005-2669-1 PMID: 15800773

Daldrup-Link HE, Rudelius M, Oostendorp RA, Jacobs VR, Simon GH, Gooding C, Rummeny EJ: Comparison of iron oxide labeling properties of hematopoietic progenitor cells from umbilical cord blood and from peripheral blood for subsequent in vivo tracking in a xenotransplant mouse model. Acad Radiol. 12(4):502-10, 2005. DOI: 10.1016/j.acra.2004.12.021 PMID: 15831425

Masi JN, Newitt D, Sell CA, Daldrup-Link H, Steinbach L, Majumdar S, Link TM. Optimization of Gadodiamide Concentration for MR Arthrography at 3 T. Am J Roentgenol. 184(6):1754-61, 2005. PMID: 15908526

Preda A, Turetschek K, Daldrup H, Floyd E, Novikov V, Shames DM, Roberts TPL, Carter WO, Brasch RC: The Choice of Region of Interest Measures in Contrast-Enhanced MRI Characterization of Experimental Breast Tumors. Invest Radiol 40(6): 349-354, 2005. PMID: 15905721

Simon GH, von Vopelius-Feldt J, Wendland M, Schlegel J, Mei-Hsiu C, Daldrup-Link HE: Ultrasmall superparamagnetic iron oxide enhanced MR imaging of normal bone marrow in rodents. Academic Radiology 12(9):1190-7, 2005. DOI: 10.1016/j.acra.2005.05.014 PMID: 16099684

Spilker M, Yao AA, Daldrup-Link HE, Shames D, Brasch RC, Vicini P: A mixture model approach to tumor classification based upon pharmacokinetic measures of tumor permeability. J Magn Reson Imag 13;22(4):549-558, 2005. DOI: 10.1002/jmri.20412 PMID: 16161077


Daldrup-Link HE, Rudelius M, Metz S, Piontek G, Settles M, Pichler B, Heinzmann U, Weinmann HJ, Schlegel J, Link TM, Rummeny EJ, Oostendorp RAJ: Cell tracking with gadophrin-2: a bifunctional contrast agent for MR imaging, optical imaging, and fluorescence microscopy. Eur J Nucl Med Mol Imaging 31(9): 1312-21, 2004. DOI: 10.1007/s00259-004-1484-2 PMID: 15138719

Metz S, Bonaterra G, Rudelius M, Settles M, Rummeny EJ, Daldrup-Link HE: Capacity of Human Monocytes to phagocytose approved iron oxide MR contrast agents. Eur Radiol 14(10):1851-8, 2004. DOI: 10.1007/s00330-004-2405-2 PMID: 15249981

Daldrup-Link HE, Okuhata Y, Wolfe A, Srivastav S, Oie S, Ferrara N, Cohen RL, Shames DM, Brasch RC: Decrease in tumor apparent permeability surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation. Microcirculation 11(5):387-96, 2004. DOI: 10.1080/10739680490457665 PMID: 15280064


Daldrup-Link HE, Rudelius M, Oostendorp RAJ, Settles M, Piontek G, Metz S, Heinzmann U, Rummeny EJ, Schlegel J, Link TM: Targeting of Hematopoietic Progenitor Cells with MR Contrast Agents. Radiology 228: 760-767, 2003. DOI: 10.1148/radiol.2283020322 PMID: 12881578

Rudelius M, Daldrup-Link HE, Heinzmann U, Piontek G, Settles M, Link TM, Schlegel J: Highly efficient paramagnetic cellular labeling by standard transfection protocols. Eur J Nucl Med Mol Imaging 30: 1038-1044, 2003. DOI: 10.1007/s00259-002-1110-0 PMID: 12567250

Daldrup-Link HE, Kaiser A, Helbich T, Werner M, Bjornerud A, Link TM, Rummeny EJ: Macromolecular contrast medium (feruglose) versus small molecular contrast medium (gadopentetate) enhanced magnetic resonance imaging: differentiation of benign and malignant breast lesions. Acad Radiol 10(11):1237-46, 2003. PMID: 14626298

Metz S, Daldrup-Link HE, Richter T, Räth C, Ebert W, Settles M, Rummeny EJ, Link TM, Piert M: Detection and quantification of breast tumor necrosis by MRI: Value of the necrosis avid contrast agent gadophrin-3. Academic Radiology 10: 484-490, 2003. PMID: 12755535

Daldrup-Link HE, Rydland J, Helbich T, Turetschek K, Haraldseth O, Link TM, Brasch RC, Shames D, Rummeny EJ: Quantification of breast tumor microvascular permeability with feruglose-enhanced MR imaging: initial phase II multicenter trial. Radiology 229(3): 885-92, 2003. DOI: 10.1148/radiol.2293021045 PMID: 14576446