Principal Investigator

Heike Daldrup-Link

Heike E. Daldrup-Link, MD

Associate Professor of Radiology,
Lucile Packard Children's Hospital,
Member, Childrens Oncology Group (COG),
Member, Molecular Imaging Program at Stanford (MIPS)
Stanford University School of Medicine

As a physician-scientist involved in the care of patients and the development of cellular imaging techniques, my goal is to develop innovative, non-invasive imaging solutions for significant clinical problems. Our research team develops broadly enabling and clinically applicable imaging technologies for detection of specific cell populations in vivo. Applications include improved cancer detection and characterization, in vivo monitoring of novel stem cell therapies and diagnosis of immune responses to stem cell transplants and solid organ transplants.

| Phone: (650) 723-8996 | Stanford Profile

Lab Members

Danielle Beecham

Danielle Beecham

Administrative Associate

As an administrative assistant and research administrator I work with the Daldrup-Link Lab to facilitate grant proposals and management. I also coordinate with Dr. Daldrup-Link and her lab members to manage ongoing and upcoming studies ensuring that they are compliant with university and sponsor policies. My academic interests are grounded in the study of International Relations and its influence on global health policies.

Christopher Klenk

Christopher Klenk

Postdoctoral Fellow

The main focus of my research concentrates on the development of radiation free imaging techniques for staging of children with cancer, particularly new whole body MR imaging techniques and "diffusion weighted imaging body scans" (DWIBS). These innovative imaging approaches are a promising radiation free alternative in tumor staging and re-staging and intend to eliminate concerns for long-term side effects from radiographic imaging procedures. I use novel iron oxide nanoparticles as MR contrast agents in order to differentiate malignant tumors from normal organs and non-cancer inflammatory processes.

|Phone: (650)724-3191 | Stanford Profile

Hossein Nejadnik

Hossein Nejadnik

Postdoctoral Fellow

I am interested in Stem Cell therapies, which hold hopes for cure of a large variety of diseases. One major concern for successful outcomes of stem cell therapies is the cell fate after implantation. As a clinician-scientist my ultimate aim for stem cell research is to develop clinically applicable, non-invasive and repeatable imaging approaches which can be used for long-term tracking of transplanted stem cells. I work on development and testing of "smart", enzyme-activatable probes, which can detect the viability and differentiation of transplanted stem cells, and their interaction with immune system.

| Phone: (650) 723-1127 Stanford Profile

Tarsheen K. Sethi

Tarsheen K. Sethi

Postdoctoral Fellow

I am interested in tumor immunology (as part of a career in hematology-oncology) and am currently involved in a translational project investigating a non-invasive method of identifying tumor associated macrophages (TAMs) in pediatric sarcomas. For this purpose, we use ferumoxytol, an iron nano-particle, off label as a contrast agent for MRI based on pre-clinical studies showing successful use of this technique. I also work with osteosarcoma and Ewing’s sarcoma cell lines in vitro to demonstrate negligible ferumoxytol uptake when compared with TAMs (M2 macrophages) using MRI, ICP-Mass Spectrometry and Staining methods.

| Phone: 650-723-0705 | Stanford Profile

Malcolm Debaun

Malcolm Debaun

Medical Student

I am currently a medical student at Stanford interested in pursuing a career in orthopedic surgery. My research primarily focuses on designing a clinically translational chondrogenic implant using stem cell technology to promote healing of cartilage defects as part of a one step intraoperative procedure.

 

Deborah Fretwell

Deborah Fretwell

Medical Student

I am investigating whether macrophage phagocytosis alters the MR signal of iron oxide nanoparticle-labeled human mesenchymal stem cells (hMSCs). We hypothesize that a static MR scan can differentiate between viable iron oxide nanoparticle-labeled hMSCs and apoptotic iron oxide-labeled hMSCs that have been engulfed by macrophages. The potential of MR imaging to detect apoptosis after stem cell transplant would improve our ability to detect post-transplant complications in patients.

 

Fanny Chapelin

Fanny Chapelin

Life Science Research Assistant

My research interest focuses on the development of cellular therapies for clinical applications. My current projects involve in vivo tracking of stem cell transplants and immune cells through MR imaging.

|Phone: (650) 308-6799

Jessica Donig

Jessica Donig

Research Coordinator

As a premedical student and technical illustrator, I am interested in the many uses of imaging and of visual information in general in research and in medicine. In particular, I am interested in the ways in which MRI and PET technology, in conjunction with novel contrast agents, can provide unique information which may allow improved tumor detection and staging with little or no ionizing radiation. I serve as coordinator of the ACR committee on pediatric imaging research and the pediatric PET/MR working group.

|Phone: (650) 281-4534

Olga Lenkov

Olga Lenkov

Life Science Research Assistant

My interest in stem cell research is to develop non-invasive and repeatable imaging approaches which can be used for long-term tracking of transplanted stem cells. I work on the development of contrast agents, which can be used to determine the viability and differentiation of the transplanted stem cells, and their interaction with the immune system.


Maryam Aghighi

Maryam Aghighi

Visiting Scholar

I am interested in the development of radiation free whole body MR imaging techniques for staging of cancer in children and investigate the role of novel iron-oxide nanoparticles as MR contrast agents. I am also working on a clinical project of ferumoxytol-enhanced MR imaging in children with kidney transplants.

| Mobile: 650-666-9773 | Office: 650-724-7978

Ali Fathi

Ali Fathi

Volunteer

I feel fully fortunate to have worked with Heike and her team since last January as it has allowed my medical career to come upon an unhampered scope. My initial work implicated ips cell differentiation to chondrocytes and genetic manipulation of ips cells to radiologically-traceable cells. Currently I am working on comparison of three evaluation systems of tumor response to therapy in Ewing sarcoma family of tumors. This clinical project assesses whether volumetric measure of response is of provably greater benefit to RECIST, a one dimensional assessment system. To its implicit credit, this work concurrently extends into an evaluation of tumor response to treatment and any potential correlation with tumor geometry.

 

Lebriz Uslu

Lebriz Uslu

Visiting Scholar

As a nuclear medicine resident, I am interested in molecular imaging, especially PET imaging, and MRI, as well as their applications in pediatric patients. Development of new imaging techniques and tracers, which can reduce the radiation dose for pediatric patients, while detecting tumor selectively is my main goal in research. I am also interested in the usage of molecular imaging to track transplanted stem cells and immune cells.

Claudio Von Schacky

Claudio Von Schacky

Visiting Student

As both an engineering student and a medical student I am interested in developing new molecular imaging techniques. The project I work on investigates novel imaging tools to diagnose stem cell rejection in vivo.

 

Marisol Zuluaga

Marisol Zuluaga

Visiting Student

As a Biomedical student, I am interested in the interaction between stem cells and biomaterials, their influence in the human body and their clinical applications.

 

Vy Thao Tran

Vy Thao Tran

Clinical Fellow

I am interested in Pediatric radiology, MR imaging, and PET/MR

Alexis Crawley

Alexis Crawley

Radiology Resident

I am interested in the application of PET/MR and particularly diffusion weighted imaging to the staging of pediatric tumors and monitoring treatment response.