Principal Investigator

Heike Daldrup-Link

Heike E. Daldrup-Link, MD

Associate Professor of Radiology,
Lucile Packard Children's Hospital,
Member, Childrens Oncology Group (COG),
Member, Molecular Imaging Program at Stanford (MIPS)
Stanford University School of Medicine

As a physician-scientist involved in the care of patients and the development of cellular imaging techniques, my goal is to develop innovative, non-invasive imaging solutions for significant clinical problems. Our research team develops broadly enabling and clinically applicable imaging technologies for detection of specific cell populations in vivo. Applications include improved cancer detection and characterization, in vivo monitoring of novel stem cell therapies and diagnosis of immune responses to stem cell transplants and solid organ transplants.

| Phone: (650) 723-8996 | Stanford Profile

Lab Members

Danielle Beecham

Danielle Beecham

Administrative Associate

As an administrative assistant and research administrator I work with the Daldrup-Link Lab to facilitate grant proposals and management. I also coordinate with Dr. Daldrup-Link and her lab members to manage ongoing and upcoming studies ensuring that they are compliant with university and sponsor policies. My academic interests are grounded in the study of International Relations and its influence on global health policies.

Hossein Nejadnik

Hossein Nejadnik

Postdoctoral Fellow

I am interested in Stem Cell therapies, which hold hopes for cure of a large variety of diseases. One major concern for successful outcomes of stem cell therapies is the cell fate after implantation. As a clinician-scientist my ultimate aim for stem cell research is to develop clinically applicable, non-invasive and repeatable imaging approaches which can be used for long-term tracking of transplanted stem cells. I work on development and testing of "smart", enzyme-activatable probes, which can detect the viability and differentiation of transplanted stem cells, and their interaction with immune system.

| Phone: (650) 723-1127 | Stanford Profile

Saeid Zanganeh

Saeid Zanganeh

Postdoctoral Fellow

My principal research interests lie in the field of biomedical imaging, especially MRI, PET, and optical imaging. I was fortunate to receive the 2014 Stanford Cancer Imaging Training (SCIT) Program postdoctoral fellowship award, and I am now working with postdoctoral research mentor Dr. Heike Daldrup-Link. My current research projects include development of cellular imaging techniques for cancer detection and therapy, with a particular focus on the uses of theranostic nanoparticles for magnetic resonance imaging.

Office: (650) 723-1127 | Phone: (530) 304-6690 | Stanford Profile

S. Meghdad Taghavi Garmestani

S. Meghdad Taghavi Garmestani

Postdoctoral Fellow

My research interests include stem cell tracking and bioprinting. My current research project involves optimizing stem cell labeling techniques with iron oxide nanoparticles for stem cell tracking with MR imaging. Through my work with the Daldrup-Link lab, I plan to pursue clinically relevant projects, which will help me develop my career as a physician-scientist.

Phone: (650) 723-1127 | Stanford Profile

Malcolm Debaun

Malcolm Debaun

Medical Student

I am currently a medical student at Stanford interested in pursuing a career in orthopedic surgery. My research primarily focuses on designing a clinically translational chondrogenic implant using stem cell technology to promote healing of cartilage defects as part of a one step intraoperative procedure.

 

Deborah Fretwell

Deborah Fretwell

Medical Student

I am investigating whether macrophage phagocytosis alters the MR signal of iron oxide nanoparticle-labeled human mesenchymal stem cells (hMSCs). We hypothesize that a static MR scan can differentiate between viable iron oxide nanoparticle-labeled hMSCs and apoptotic iron oxide-labeled hMSCs that have been engulfed by macrophages. The potential of MR imaging to detect apoptosis after stem cell transplant would improve our ability to detect post-transplant complications in patients.

 

Jacqueline Vuong

Jacqueline Vuong

Medical Student

As a medical student with an interest in pursuing a career in radiology, I find it important to improve methods of diagnostic imaging for detecting and staging tumors. I have been assisting with the development of a non-invasive method of identifying tumor associated macrophages (TAMs) in-vivo in patients with osteosarcoma, Ewing sarcoma, and lymphoma through the use of the USPIO ferumoxytol. I am also assisting with an in-vitro study to demonstrate that the respective tumor cells take up negligible amounts of ferumoxytol in comparison to TAMs.

Office: (650) 723-1127

Jessica Donig

Jessica Donig

Research Coordinator

As a premedical student and technical illustrator, I am interested in the many uses of imaging and of visual information in general in research and in medicine. In particular, I am interested in the ways in which MRI and PET technology, in conjunction with novel contrast agents, can provide unique information which may allow improved tumor detection and staging with little or no ionizing radiation. I serve as coordinator of the ACR committee on pediatric imaging research and the pediatric PET/MR working group.

|Phone: (650) 281-4534

Olga Lenkov

Olga Lenkov

Life Science Research Assistant

My interest in stem cell research is to develop non-invasive and repeatable imaging approaches which can be used for long-term tracking of transplanted stem cells. I work on the development of contrast agents, which can be used to determine the viability and differentiation of the transplanted stem cells, and their interaction with the immune system.


Maryam Aghighi

Maryam Aghighi

Visiting Scholar

I am interested in the development of radiation free whole body MR imaging techniques for staging of cancer in children and investigate the role of novel iron-oxide nanoparticles as MR contrast agents. I am also working on a clinical project of ferumoxytol-enhanced MR imaging in children with kidney transplants.

| Mobile: 650-666-9773 | Office: 650-724-7978

Ziyan Sun

Ziyan Sun

Visiting Radiologist

I am interested in investigating stem cell therapies for bone defect repair. The main focus of my research is to establish non-invasive, clinically applicable, and repeatable imaging approaches for detecting host immune responses to stem cell transplants in bone defects. These imaging techniques will facilitate non-invasive predictions of stem cell engraftment outcomes and improve our ability to develop successful approaches for regenerative medicine.

Office: 650-723-1127

Ziyan Sun

Catherine Zhao

Visiting Student

As a high school student, I would like to explore and expand my knowledge in different medical fields. I am currently interested in improving the diagnosis and treatment of cancer.

Office: 650-723-1127

Alexis Crawley

Alexis Crawley

Radiology Resident

I am interested in the application of PET/MR and particularly diffusion weighted imaging to the staging of pediatric tumors and monitoring treatment response.